Several factors combine to cause triggered arrhythmias in heart failure.

2004 MAY 24 - (NewsRx.com & NewsRx.net) -- Further understanding of cellular factors responsible for triggered arrhythmias will lead to new treatments, researchers say.

According to a study from the United States, "Ventricular tachycardia in nonischemic heart failure (HF) initiates by a nonreentrant mechanism that appears to be due to triggered activity primarily from delayed afterdepolarizations that arise from altered cellular Ca handling and ionic currents.

In HF, factors that conspire to enhance triggered arrhythmias include upregulated Na/Ca exchange, preserved beta-adrenergic responsiveness, and decreased I-K1," wrote S.M. Pogwizd and colleagues, …